AGIO broke out of the downtrend but didn't close on the highs of the day. Also the volume on the breakout was very less understandably due to holiday season. It will be an interesting round of events next week to get an idea as to where AGIO's is going. MACD and RSI are showing bullish signs. All in all if it can consolidate a little over the downtrend line there is a definite possibilities of a long term trend reversal.